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M94A0247.TXT
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1994-10-08
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Document 0247
DOCN M94A0247
TI CD3-dependent lymphocyte activation by human T cell leukaemia virus type
I-producing T cells.
DT 9412
AU Kimata JT; Wong FH; Ratner L; Department of Medicine, Washington
University School of Medicine,; St Louis, Missouri 63110.
SO J Gen Virol. 1994 Sep;75 ( Pt 9):2433-7. Unique Identifier : AIDSLINE
MED/94358746
AB Human T cell leukaemia virus type I-(HTLV-I) transformed cells are
capable of stimulating the proliferation of normal T lymphocytes, or
stimulating interleukin 2 expression in Jurkat T lymphoid cells. This
effect is mediated by the CD2/lymphocyte function-associated antigen 3
(LFA-3) adhesion/signalling pathway. The current work demonstrates that
CD3 is also required for this effect, suggesting that the T cell
receptor (TCR)/CD3 complex is mediating this effect. However, this
effect does not appear to be due to a superantigen since no change in
TCR expression was found after HTLV-I-mediated proliferation, nor was
proliferation inhibited by an antibody against the specific TCR
expressed on Jurkat cells (TCR V beta 8).
DE Adult Antigens, CD/*PHYSIOLOGY Antigens, CD3/*PHYSIOLOGY Antigens,
Differentiation, T-Lymphocyte/PHYSIOLOGY Cells, Cultured Human HLA-D
Antigens/IMMUNOLOGY HTLV-I/*IMMUNOLOGY *Lymphocyte Transformation
Receptors, Antigen, T-Cell, alpha-beta/IMMUNOLOGY Receptors,
Immunologic/PHYSIOLOGY Support, Non-U.S. Gov't Support, U.S. Gov't,
P.H.S. T-Lymphocytes/*IMMUNOLOGY JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).